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HypertensionCohort study

Evaluation of hypertension-related complications 10 years after implementation of risk assessment and management programme for hypertension: a target trial emulation

Eur J Prev CardiolPublished

  • Target trial emulation (prospective cohort)
  • propensity-score matched
  • sequential trials
  • stabilized inverse probability treatment weights
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Authors' conclusion

Risk assessment and management programme for hypertension supplementing usual care associated with reduced relative risk of CVD and all-cause mortality risks in patients with HT by 9 and 12%, respectively, compared with patients receiving usual care only

Study context

Population
Patients with hypertension in primary care, Hong Kong electronic health records, January 2012 to December 2018person-trials after matching
Participants
337,990 patients
Exposure
RAMP-HT plus usual care vs usual care only
  • RAMP-HTn = 168,995
  • Usual caren = 168,995reference
Outcome
CVD and all-cause mortality
Follow-up
10 years

Main finding

As reported in the abstract

RAMP-HT

16.54 (95% CI 16.31, 16.78)

CVD incidence rate (IR) (cases/1000 person-years) · All-cause mortality IR (cases/1000 person-years) 9.41 (95% CI 9.24, 9.59)

Usual care

18.40 (95% CI 18.10, 18.69)

CVD IR (cases/1000 person-years) · All-cause mortality IR (cases/1000 person-years) 12.23 (95% CI 12.00, 12.47)

RAMP-HT vs Usual careHazard ratio (95% CI)
CVD
0.91(0.89–0.93)
all-cause mortality
0.88(0.86–0.90)

Observational data: associations, not effects.

Original publication

Evaluation of hypertension-related complications 10 years after implementation of risk assessment and management programme for hypertension: a target trial emulation. Eur J Prev Cardiol. Published 4 August 2025. doi:10.1093/eurjpc/zwaf480
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Summarised from the published abstract; every number is checked against it