Pulmonary vascular disease & thromboembolismDiagnostic or prognostic study
Evaluation of LCN2 and miR-8078 as diagnostic biomarkers for congenital heart disease-associated pulmonary arterial hypertension
- diagnostic biomarker study
Authors' conclusion
Plasma LCN2 and miR-8078 are significantly elevated in patients with CHD-PAH and correlate positively with hemodynamic severity. LCN2, in particular, serves as a robust independent biomarker for the diagnosis and severity assessment of CHD-PAH. Consequently, LCN2 and miR-8078 hold promise as potential non-invasive biomarkers for the diagnosis and severity assessment of CHD-PAH.
Study context
- Population
- Patients with congenital heart disease assessed by right heart catheterization, stratified by mean pulmonary arterial pressure (mPAP)patients diagnosed via right heart catheterization · non-PAH 28 · mild PAH 21 · moderate-to-severe PAH 27
- Participants
- Seventy-six patients
- Comparison
- Plasma LCN2 and miR-8078 for diagnosing moderate-to-severe PAH, analysed using receiver operating characteristic curves
- non-PAHn = 28
- mild PAHn = 21
- moderate-to-severe PAHn = 27
Performance
As reported in the abstract
Further findings
| Outcome | non-PAH | mild PAH | moderate-to-severe PAH |
|---|---|---|---|
| Relative miR-8078 expression | 2.3 ± 1.3 fold | Not reported in the abstract | 4.2 ± 1.1 fold |
- Relative miR-8078 expression: P < .05
Correlation with mPAP
- LCN2 r
- 0.691, P < .001
- miR-8078 r
- 0.481, P < .001
Correlation with pulmonary artery systolic pressure
- LCN2 r
- 0.579, P < .001
- miR-8078 r
- 0.391, P < .001
Correlation of LCN2 with miR-8078 expression
- r
- 0.407, P < .001
AUC for diagnosing moderate-to-severe PAH
- LCN2
- 0.883
- miR-8078
- 0.749
- combined model
- 0.896
- combined model did not significantly differ from LCN2 alone
Predictors of CHD-PAH
- Univariate: both LCN2 and miR-8078 significant predictors
- LCN2 independent risk factor
Original publication
Summarised from the published abstract; every number is checked against it