Prevention & lipidsCohort study
Evaluation of Lipoprotein(a) as a Prognostic Marker of Extracoronary Atherosclerotic Vascular Disease Progression
- Prospective cohort study
Authors' conclusion
High concentrations of Lp(a) are associated with both incident extracoronary atherosclerotic vascular disease and progression to major complications.
Study context
- Population
- UK Biobank participants with prospectively measured Lp(a)UK Biobank
- Participants
- 460,544 participants
- Exposure
- Lp(a) concentrations and incident extracoronary atherosclerotic disease and its progression
- Outcome
- Incident PAD and incident carotid artery stenosis; progression to first major adverse limb event and first stroke
- Follow-up
- Median 13.6 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Lp(a) per 75 nmol/Lincident PAD
1.18(1.15–1.20)
P < 0.0001Lp(a) per 75 nmol/Lincident carotid stenosis
1.17(1.13–1.20)
P < 0.0001Per 75 nmol/L, as printed
- High Lp(a) vs Normal Lp(a) · major adverse limb event among participants with peripheral artery disease (PAD)
- risk 1.57 (95% CI 1.14–2.16); P = 0.006
- High Lp(a) vs Normal Lp(a) · ischemic stroke among participants with carotid stenosis; not significant
- risk 1.40 (95% CI 0.81–2.40); P = 0.228
- Incident PAD
- 6347 (1.4%)
- Incident carotid stenosis
- 1972 (0.43%)
- Prevalent PAD progressing to major adverse limb event
- 196 (2.7%)
- Prevalent carotid stenosis progressing to stroke
- 67 (1.9%)
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Median Lp(a) concentration by disease status | No atherosclerotic vascular disease median 19.5 (IQR 7.6–73.5) nmol/L · Incident PAD median 25.3 (IQR 8.3–107.3) nmol/L · Progression to major adverse limb event median 33.3 (IQR 8.7–158.2) nmol/L · Incident carotid stenosis median 29.5 (IQR 8.5–116.3) nmol/L · Carotid stenosis progression to stroke median 37.8 (IQR 11.1–158.3) nmol/L |
Median Lp(a) concentration by disease status
- Median Lp(a) significantly different vs those without disease
Original publication
Evaluation of Lipoprotein(a) as a Prognostic Marker of Extracoronary Atherosclerotic Vascular Disease Progression. Circulation. Published 28 July 2025. doi:10.1161/circulationaha.124.073579
Summarised from the published abstract; every number is checked against it