Event-Weighted Desaturation Burden and Cardiovascular Mortality in Sleep Apnoea: Findings from a Large Community-Based Prospective Cohort
Authors' conclusion
EWDB was independently associated with cardiovascular mortality and provided incremental prognostic information beyond established clinical and sleep-related factors in this cohort. By integrating respiratory event intensity, cumulative burden, and inter-event interval regularity, EWDB may better characterize cardiovascular stress related to sleep-disordered breathing.
Study context
- Population
- Adults from the Sleep Heart Health Study with baseline polysomnography and adjudicated follow-upadults analysed
- Participants
- 4,904 adults
- Exposure
- Event-weighted desaturation burden (EWDB) vs apnoea-hypopnoea index (AHI) and established hypoxic metrics for cardiovascular mortality
- Outcome
- Cardiovascular mortality
- Follow-up
- Median ≈11 years
Methodological detailsfully adjusted multivariable Cox models
- Fully adjusted multivariable Cox models
Main finding
As reported in the abstract
Cardiovascular deaths
341
Observational data: associations, not effects.
Further findings
Incremental risk stratification
- Incorporating EWDB into a comprehensive clinical model provided incremental risk stratification
Fatal coronary heart disease and incident heart failure
- Similar robust associations were observed
Original publication
Event-Weighted Desaturation Burden and Cardiovascular Mortality in Sleep Apnoea: Findings from a Large Community-Based Prospective Cohort. Eur J Prev Cardiol. Published 12 October 2026. doi:10.
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