Cardio-oncology & otherCohort study
Evolution of Management and Outcomes of Infective Endocarditis After Introducing the Endocarditis Team
- prospective cohort study
- divided into 3 cohorts
- adjusted for potential case mix
Authors' conclusion
There were more referrals and rediscussions, but less need for additional advice, reflecting increased familiarity with and a learning effect of the ET. CT and PET-CT were used more often. Mortality did not change over time and remained high.
Study context
- Population
- Patients with infective endocarditis discussed by an endocarditis team (ET) since 2016total cohort · 2016-2018 223 · 2019-2021 364 · 2022-2024 455
- Participants
- 1,042 patients
- Exposure
- Trends over time for the number of discussions, diagnostics, ET recommendations, treatment, and outcomes
- 2016-2018n = 223
- 2019-2021n = 364
- 2022-2024n = 455
Main finding
As reported in the abstract
increased with
18.2%
P
P < 0.001
Observational data: associations, not effects.
Further findings
Number of discussions per patient
- increased with, per diagnosis-year
- 3%
- P
- P = 0.006
Percentage of patients with positive blood cultures
- decreased with
- 17.5%
- P
- P < 0.001
Cardiac computed tomography (CT) usage
- increased with
- 3.1%
- P
- P = 0.028
Positron emission tomography (PET) CT usage
- increased with
- 12.5%
- P
- P < 0.001
Advice for additional diagnostic tests
- decreased by
- 11.6%
- P
- P < 0.001
Treatment change
- decreased by
- 18.3%
- P
- P < 0.001
Reclassification of the initial diagnosis
- increased with
- 8.3%
- P
- P = 0.045
Relapse and reinfection rates
- Relapse did not change
- P = 0.82
- Reinfection did not change
- P = 0.98
One-year survival
- approximately
- 80%
- remained stable
- P = 0.62
Original publication
Summarised from the published abstract; every number is checked against it