Heart failure & cardiomyopathiesResearch article
Excess and Dysfunctional Fat as a Primary Driver of Heart Failure With Preserved Ejection Fraction
- Narrative review
Authors' conclusion
In conclusion, the role of excess and dysfunctional fat in the genesis of HFpEF is well recognized, likely representing a primary or major upstream contributing cause in the large majority of patients.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF)
Main finding
As reported in the abstract
Role of excess and dysfunctional fat in HFpEF
- Epidemiological and Mendelian randomization studies show a strong link between central obesity, visceral adiposity and HFpEF
- Experimental studies confirm a causal role of proinflammatory adipose tissue secretions in HFpEF pathogenesis
- AHA recognizes excess and dysfunctional fat as the major upstream driver of hypertension, T2DM, metabolic dysfunction-associated steatotic liver disease and CKD, the common comorbidities of HFpEF
- Adipose signaling may amplify HFpEF even when caused by other disorders (eg, pressure overload)
Original publication
Excess and Dysfunctional Fat as a Primary Driver of Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. Published 29 March 2026. doi:10.1016/j.jchf.2026.103046
Summarised from the published abstract; every number is checked against it