Arrhythmias & electrophysiology
Exercise exposure and arrhythmic patterns in arrhythmogenic right ventricular cardiomyopathy
Authors' conclusion
Associations with exercise was consistently associated with VA, but varied for AF by measure and time point. The graded distribution does not establish thresholds or sequential progression. Co-occurrence may reflect shared exercise history, disease susceptibility, and differential surveillance rather than a direct relationship.
Study context
- Population
- Genotype-positive probands and relatives across the arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnostic spectrum49% women, mean age 39±17 years, median follow-up 13.5 years
- Participants
- 122 probands
- Outcome
- AF and VA prevalence
- Follow-up
- First visit to last
Methodological detailsretrospective exercise assessment by structured interview
- Retrospective exercise assessment by structured interview
Main finding
As reported in the abstract
Atrial fibrillation (AF) prevalence increased from 5% to
21%
Ventricular arrhythmias (VA) prevalence increased from 26% to
37%
Median onset age, AF
55 years
Median onset age, VA
36 years
Observational data: associations, not effects.
Further findings
Exercise and VA · first visit and last follow-up
- Both exercise measures were associated with VA at both time points
Exercise and AF
- Exercise dose was associated with AF at first visit and intensity at last follow-up
Exercise dose across arrhythmic patterns
- Median exercise dose increased across groups with no arrhythmia, AF only, VA only, and both
Association between AF and VA · last follow-up
- Adjusted OR, adjusted for exercise intensity
- 2.43, 95% CI 0.85-6.97, p=0.10
- Attenuated after adjustment for exercise intensity
Original publication
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