Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults: A Randomized Clinical Trial
Primary result · LV mass to end-diastolic volume ratio (term-born)Result — go to the resultDifference −3.43 95% CI −6.29 to −0.56Authors' conclusion
Aerobic exercise training induces improved myocardial function but not cardiac structure in preterm-born adults.
Study context
- Population
- Adults (aged 18–35 years) with elevated blood pressure or stage 1 hypertension, born preterm (<37 weeks' gestation) or at termrandomized, 100 completed CMR scans at baseline and after the 16-week intervention · exercise intervention group (CMR) 47 · exercise, term-born 26 · exercise, preterm-born 21 · controls (CMR) 53 · controls, term-born 32 · controls, preterm-born 21
- Participants
- 203 adults
- Comparison
- 16-week aerobic exercise intervention vs control group, in term-born and preterm-born participants
- Exercise intervention groupn = 47
- Controlsn = 53
Methodological detailsprespecified cardiovascular magnetic resonance imaging (CMR) substudy
- Prespecified cardiovascular magnetic resonance imaging (CMR) substudy
Primary result
As reported in the abstract
LV mass to end-diastolic volume ratio (term-born) · 16 weeks
Difference
−3.43
95% CI −6.29 to −0.56
interaction P = 0.027
Exercise intervention groupvs controls
difference −3.43 (95% CI −6.29 to −0.56); interaction P = 0.027
Further findings
| Outcome | Difference (mL/m²) (95% CI) | P value | |
|---|---|---|---|
| RV stroke volume index (term-born) · 16 weeksIncreased with exercise | 5.53 (2.60–8.47) | interaction P = 0.076 | |
| −50510Difference, mL/m² (linear scale) |
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| LV basal- and mid-ventricular circumferential strain (preterm-born) · 16 weeksExercise intervention groupvs controlsBasal; strain increased with exercise | −1.33 (−2.07 to −0.60) | interaction P = 0.057 | |
| LV basal- and mid-ventricular circumferential strain (preterm-born) · 16 weeksExercise intervention groupvs controlsMid-ventricular; strain increased with exercise | −1.54 (−2.46 to −0.63) | interaction P = 0.046 | |
| −3−2−101Difference (linear scale) |
| Outcome | Difference (95% CI) | P value |
|---|---|---|
| RV global longitudinal strain (preterm-born) · 16 weeksIncreased with exercise, as printed | 1.99% (−3.12 to −0.87) | interaction P = 0.053 |
Cardiac structural indices (preterm-born)
- No significant effects were observed for cardiac structural indices in preterm-born participants
Myocardial deformation parameters (term-born)
- No significant effects were observed for myocardial deformation parameters in term-born participants
Original publication
Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults: A Randomized Clinical Trial. JACC Adv. Published 28 April 2025. doi:10.
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