Prevention & lipidsCohort study
Exercise intensity and cardiac disease development in carriers of titin truncating variants
- Cohort study
Authors' conclusion
In carriers of TTNtv, vigorous physical activity was not associated with LVSD and LTA development.
Study context
- Population
- Carriers of likely pathogenic (LP) or P titin truncating variants (TTNtv), patients and family members73% male
- Participants
- 117 carriers
- Exposure
- Athletes vs non-athletes
- Athletesn = 38
- Outcome
- LV systolic dysfunction (LVEF < 45%)
Main finding
Left ventricular systolic dysfunction (LVSD) (LVEF < 45%)
Adjusted odds ratio
0.663
95% CI 0.261–1.685
P 0.388
Vigorous exercise vs Non-athletes
adjusted OR 0.663 (95% CI 0.261–1.685); P 0.388
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Life-threatening ventricular arrhythmias (LTA)
- Vigorous exercise not associated with LTA
- P = 0.607
Non-LTA ventricular arrhythmias
- Vigorous exercise not associated with non-LTA
- P = 0.648
Supraventricular arrhythmias (AF/AFL)
- Vigorous exercise not associated with supraventricular arrhythmias
- P = 0.701
Lifetime metabolic equivalents (METs) × hours as continuous variable
- Comparable results
Original publication
Exercise intensity and cardiac disease development in carriers of titin truncating variants. Eur J Prev Cardiol. Published 25 February 2025. doi:10.1093/eurjpc/zwaf094
Summarised from the published abstract; every number is checked against it