Heart failure & cardiomyopathiesRandomised controlled trial
Exercise Training in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction: A Randomized Clinical Trial
- Randomised controlled trial
- blinded outcome analysis
Authors' conclusion
In patients with hypertrophic cardiomyopathy without left ventricular outflow tract obstruction, a 12-week moderate-intensity exercise training program resulted in reduced left ventricular filling pressures at mild exertion and improved exercise performance.
Study context
- Population
- Patients with hypertrophic cardiomyopathy without LV outflow tract obstruction51 (86%) completed follow-up
- Participants
- 59 patients
- Comparison
- Supervised moderate-intensity exercise training vs usual activity
- Primary endpoint
- Change in invasively measured pulmonary capillary wedge pressure during mild exercise (25 W)
- Follow-up
- Baseline to week 12
Primary result
As reported in the abstract
Change in 25-W pulmonary capillary wedge pressure · week 12
Between-group difference
4.0 mm Hg
95% CI 0.7–7.3
P = 0.018
By group
Exercise
−2.8
mean change · SD 6.8 · mm Hg
Usual activity
+1.2
mean change · SD 4.9 · mm Hg
Exercise vs Usual activity
between-group difference 4.0 mm Hg (95% CI 0.7–7.3); P = 0.018
Secondary outcomes
| Outcome | between-group difference (95% CI) | P value | |
|---|---|---|---|
| Ventilatory efficiency (VE/VCO2) slope · week 12 · improved with exercise | 2.0 (0.6–3.5) | P = 0.006 | |
| −2024Difference (linear scale) |
| Outcome | Exercise | Usual activity | Estimate | P value |
|---|---|---|---|---|
| Peak oxygen consumption · week 12 | mean change +1.8 (SD 2.0) mL·kg⁻¹·min⁻¹ | mean change −0.3 (SD 3.1) mL·kg⁻¹·min⁻¹ | P = 0.005 | |
| Peak cardiac index · week 12 | mean change +0.38 (SD 1.38) L·min⁻¹·m⁻² | mean change −0.85 (SD 1.20) L·min⁻¹·m⁻² | P = 0.002 | |
| KCCQ physical limitation score · week 12 | mean change +8.4 (SD 12.0) points | mean change +0.7 (SD 6.8) points | P = 0.034 | |
| KCCQ quality-of-life score · week 12 | mean change +8.7 (SD 18.0) points | mean change 0.7 (SD 4.0) points | P = 0.01 |
Overall Kansas City Cardiomyopathy Questionnaire score · week 12
- Change similar between groups
Echocardiographic diastolic function and natriuretic peptides · week 12
- No significant changes
Original publication
Exercise Training in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction: A Randomized Clinical Trial. Circulation. Published 8 November 2024. doi:10.1161/circulationaha.124.070064
Summarised from the published abstract; every number is checked against it