Acute cardiac care & resuscitationRandomised controlled trial
Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial
- Randomised controlled trial
- prospective
- parallel
- multicentre
- open-label
- superiority
Authors' conclusion
In adult patients without ST elevation, transfer to a cardiac arrest centre following resuscitated cardiac arrest in the community did not reduce deaths.
Study context
- Population
- Adults (≥18 years) with return of spontaneous circulation after OHCA without ST elevation, London, UK411 and 412 in primary analysis
- Participants
- 862 adults
- Comparison
- Expedited delivery to a cardiac arrest centre vs standard care
- Cardiac arrest centren = 431
- Standard caren = 431reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 30 days
Primary result
30-day mortality
Unadjusted RR for survival
1.00
95% CI 0.90–1.11
P = 0.96
Events by treatment group
Cardiac arrest centre vs Standard care
unadjusted RR for survival 1.00 (95% CI 0.90–1.11); P = 0.96
As reported in the abstract
Safety
Serious adverse events (none deemed related to the trial intervention)
- Serious adverse events (none deemed related to the trial intervention): ITT population (414 vs 413)
Original publication
Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial. Lancet. Published 27 August 2023. doi:10.1016/s0140-6736(23)01351-x
Summarised from the published abstract; every number is checked against it