Arrhythmias & electrophysiologyCohort study
Exploring Mechanical Synchrony and Myocardial Work Across Different Pacing Locations Within the Left Bundle Branch
- prospective cohort study
Authors' conclusion
In patients with preserved LV ejection fraction, mechanical synchrony and work efficiency were similar across LBB pacing sites. These findings support a pragmatic approach centered on achieving conduction system capture rather than targeting specific anatomical locations.
Study context
- Population
- Patients with preserved left ventricular (LV) ejection fraction who received left bundle branch pacing (LBBP) for bradycardia indications106 with central or peripheral LBB capture classified
- Participants
- 114 patients
- Exposure
- central and peripheral LBB captures; intrinsic vs paced beats
- Central LBB capturen = 60
- Peripheral LBB capturen = 46
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Global longitudinal strain and myocardial work indices (global work index, global constructive work, global wasted work, global work efficiency) · follow-up
- No significant differences between central and peripheral LBB captures
Global work efficiency, global work index, global constructive work, global wasted work: LBBP vs intrinsic rhythm
- No significant differences compared with intrinsic rhythm; changes from intrinsic to paced rhythm similar between study groups
- within-patient comparisons in patients with intrinsic rhythm
Original publication
Summarised from the published abstract; every number is checked against it