Prevention & lipidsCohort study
External validation and head-to-head comparison of CUORE and SCORE2 cardiovascular risk scores in an Italian primary care-administrative cohort
- Retrospective cohort study (external validation of risk scores)
- head-to-head comparison
- primary care-administrative cohort
Authors' conclusion
In this real-world Italian cohort, CUORE and SCORE2 provided robust ordinal risk stratification and moderate discrimination at 10 years. Absolute risk estimates were sensitive to administrative endpoint mapping and recalibration strategy
Study context
- Population
- Adults in ATS Milan primary care (baseline 2007–2009), linked to hospital discharge and mortality registries
- Participants
- 38,101 adults
- Exposure
- CUORE vs SCORE2
- Outcome
- First fatal or non-fatal MI or stroke
- Follow-up
- 10 years
Main finding
As reported in the abstract
Discrimination (IPCW time-dependent AUC)
| Group | AUC |
|---|---|
| SCORE2 | 0.713-0.720 |
| CUORE | 0.730-0.741 |
Observational data: associations, not effects.
Further findings
Event rates, broad vs strict administrative ascertainment
Broad
Strict
Event rates, broad vs strict administrative ascertainment
- Broad ascertainment did not materially change AUC
Calibration
- SCORE2 showed more stable calibration; CUORE showed calibration slopes <1
Original publication
External validation and head-to-head comparison of CUORE and SCORE2 cardiovascular risk scores in an Italian primary care-administrative cohort. Eur J Prev Cardiol. Published 10 July 2026. doi:10.1093/eurjpc/zwag361
Summarised from the published abstract; every number is checked against it