Cardiometabolic & kidneyCohort study
Extracellular vesicle signature is associated with cardio-metabolic improvement after bariatric surgery
- Prospective cohort study
Authors' conclusion
Non-conventionally measured vaso-inflammatory-metabolic signatures, and in particular EV profiling, are associated with CV-metabolic outcome after BS
Study context
- Population
- Patients with severe obesity undergoing bariatric surgery
- Participants
- 111 patients
Main finding
As reported in the abstract
Association of vaso-inflammatory-metabolic markers and EV profiling with CV-metabolic outcome after BS · 1 year (T12) and 3 years (T36) post-BS
- Baseline traditional cardiovascular (CV) risk factors unable to discriminate patients by post-surgical CV-metabolic outcome
- Discrimination achieved combining post-BS decrease in serum amyloid associated protein, IL-6, TNF-α and insulin, increase in GLP-1, ghrelin, PYY and bile acids, and changes in extracellular vesicles (EV) profiling
- Baseline signature of reduced EV surface antigens and single EV markers (endothelium, platelets, inflammatory cells) discriminated patients by post-surgical CV-metabolic outcome
Observational data: associations, not effects.
Further findings
Body weight · T36
- Cumulative reduction
- 30 Kg and 32.8% BMI
- Median body weight (BW) decreased from 111 to 77 Kg
- All traditional CV risk factors improved after bariatric surgery (BS)
Original publication
Extracellular vesicle signature is associated with cardio-metabolic improvement after bariatric surgery. Eur J Prev Cardiol. Published 5 September 2025. doi:10.1093/eurjpc/zwaf561
Summarised from the published abstract; every number is checked against it