Acute cardiac care & resuscitationRandomised controlled trial
Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery
- Randomised controlled trial
- double-blind
- 2 tertiary hospitals in Spain
Authors' conclusion
The use of a nonselective EBP device connected to the CPB circuit in a nonemergent population of patients undergoing cardiac surgery was associated with a significant reduction of CSA-AKI in the first 7 days after surgery.
Study context
- Population
- Adults undergoing nonemergent cardiac surgery at high risk for cardiac surgery-associated acute kidney injury (CSA-AKI)
- Participants
- 343 adults
- Comparison
- Extracorporeal blood purification vs standard care during cardiopulmonary bypass (CPB)
- Extracorporeal blood purification (EBP)n = 169
- Standard caren = 174reference
- Primary endpoint
- Rate of cardiac surgery-associated AKI
- Follow-up
- 7 days after randomization
Primary result
As reported in the abstract
Adjusted difference
10.4%
95% CI 2.3%–18.5%
P = 0.01
By group
EBP vs Standard care
adjusted difference 10.4% (95% CI 2.3%–18.5%); P = 0.01
Secondary outcomes
Predefined clinical secondary and post hoc exploratory end points
- No significant differences in most end points
- P > 0.05
CSA-AKI by subgroup (sensitivity analysis)
- EBP more effective in CKD, DM, hypertension, LVEF <40% and BMI <30
Safety
Adverse events
- No differences between groups in adverse events tracking
Original publication
Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery. JAMA. Published 5 November 2024. doi:10.1001/jama.2024.20630
Summarised from the published abstract; every number is checked against it