Acute cardiac care & resuscitationRandomised controlled trial
Extracorporeal Life Support in Infarct-Related Cardiogenic Shock
- Randomised controlled trial
- multicentre
Authors' conclusion
In patients with acute myocardial infarction complicated by cardiogenic shock with planned early revascularization, the risk of death from any cause at the 30-day follow-up was not lower among the patients who received ECLS therapy than among those who received medical therapy alone.
Study context
- Population
- Patients with acute MI complicated by cardiogenic shock with planned early revascularization417 analysed
- Participants
- 420 patients
- Comparison
- Early extracorporeal life support (ECLS) plus usual medical treatment vs usual medical treatment alone
- ECLSn = 209
- Controln = 208reference
- Primary endpoint
- Death from any cause
- Follow-up
- 30 days
Primary result
As reported in the abstract
Relative risk
0.98
95% CI 0.80–1.19
P = 0.81
Events by treatment group
ECLS vs Control
RR 0.98 (95% CI 0.80–1.19); P = 0.81
Further findings
Median, days
| Outcome | ECLS | Control | median difference (day) (95% CI) | |
|---|---|---|---|---|
| Duration of mechanical ventilation | 7 (IQR 4–12) | 5 (IQR 3–9) | 1 (0–2) | |
| −10123Difference, day (linear scale) |
Safety
| Outcome | ECLS | Control | RR (95% CI) | |
|---|---|---|---|---|
| Moderate or severe bleeding | 23.4% | 9.6% | 2.44 (1.50–3.95) | |
| Peripheral vascular complications warranting intervention | 11.0% | 3.8% | 2.86 (1.31–6.25) | |
| 0.10.31310Relative risk (log scale) |
Original publication
Extracorporeal Life Support in Infarct-Related Cardiogenic Shock. N Engl J Med. Published 26 August 2023. doi:10.1056/nejmoa2307227
Summarised from the published abstract; every number is checked against it