Coronary disease & ACSResearch article
Extreme Temperature Events, Fine Particulate Matter, and Myocardial Infarction Mortality
- Time-stratified case-crossover study
Authors' conclusion
This study provides consistent evidence that exposure to both ETEs and PM2.5 is significantly associated with an increased odds of MI mortality, especially for women and older adults, and that heat wave interacts synergistically with PM2.5 to trigger MI deaths but cold spell does not.
Study context
- Population
- Myocardial infarction (MI) deaths in Jiangsu province, China, 2015–2020
- Participants
- 202,678 MI deaths
- Comparison
- Exposure to extreme temperature events and PM2.5 and their interaction
- Outcome
- MI mortality associated with ETEs and PM2.5, and their interactive effects
Main finding
As reported in the abstract
Heat wave, OR range across ETE definitions (lowest)
1.18 (95% CI, 1.14-1.21)
Heat wave, OR range across ETE definitions (highest)
1.74 (1.66-1.83)
Cold spell, OR range across ETE definitions (lowest)
1.04 (1.02-1.06)
Cold spell, OR range across ETE definitions (highest)
1.12 (1.07-1.18)
Further findings
MI deaths attributable to extreme temperature events (ETEs) and PM2.5 above WHO interim target 3 (37.5 μg/m3)
- Attributable fraction, up to
- 2.8%
Vulnerable subgroups
- Women and older adults more vulnerable to ETEs and PM2.5
- Interactive effects did not vary across sex, age or socioeconomic status
Original publication
Summarised from the published abstract; every number is checked against it