Heart failure & cardiomyopathiesCohort study
Factors Associated with the Use of Guideline-Directed Medical Therapy in Patients with Left Ventricular Assist Device
- Retrospective cohort study
- single-centre
Authors' conclusion
While advancing age is associated with lower use of GDMT in HM3 recipients, other patient factors do not adequately explain low prescription rates.
Study context
- Population
- Patients with a HeartMate 3 (HM3) left ventricular assist device (LVAD)
- Participants
- 270 patients
- Outcome
- Patient factors associated with GDMT use (GDMT score 0-8)
- Follow-up
- Past 12 months
Main finding
As reported in the abstract
GDMT use and its predictors
- Median guideline-directed medical therapy (GDMT) score
- 3 ± 1.7
- GDMT score of 3 or lower
- 155 patients (57.4%)
- Beta-blocker (BB) prescription rate
- 50%
- ACEi/ARB/angiotensin receptor-neprilysin inhibitor (ARNI) prescription rate
- 74.1%
- SGLT2i prescription rate
- 14.8%
- Mineralocorticoid receptor antagonist (MRA) prescription rate
- 47%
- ISDN/HYD prescription rate
- 19.6%
Observational data: associations, not effects.
Further findings
Predictors of individual drug use (multivariable)
- RV dysfunction linked to non-use of BB
- Age and Black race associated with non-use of MRA and use of ISDN/HYD
- No significant predictors for other therapies
Original publication
Factors Associated with the Use of Guideline-Directed Medical Therapy in Patients with Left Ventricular Assist Device. Eur J Heart Fail. Published 17 March 2025. doi:10.1002/ejhf.3591
Summarised from the published abstract; every number is checked against it