Coronary disease & ACSCohort study
Familial risk of myocardial infarction with non-obstructive and obstructive coronary arteries: a nation-wide cohort study
- Register-based cohort study
- nation-wide
Authors' conclusion
No increased familial risk of MINOCA was observed for MINOCA patients whereas there was an increased familial risk for MI-CAD when compared to control subjects.
Study context
- Population
- First-degree relatives of myocardial infarction with non-obstructive coronary arteries (MINOCA) cases, MI-CAD cases and control subjects, identified in 1995–2020
- Participants
- 15,462 / 204,424 / 38,220
- Exposure
- First-degree relatives of MINOCA or MI-CAD cases vs control subjects
- MINOCAn = 15,462
- MI-CADn = 204,424
- Controln = 38,220reference
- Outcome
- Familial risk of MINOCA and MI-CAD in first-degree relatives
Main finding
As reported in the abstract
Each group vs controlHazard ratio (95% CI)
MINOCAMINOCA in relatives; age- and sex-adjusted; MINOCA in 1.0% of relatives; mean follow-up 8.1 ± 4.2 years
0.99(0.80–1.23)
MINOCAMI-CAD in relatives; age- and sex-adjusted; MI-CAD in 9.7% of relatives
1.10(1.03–1.18)
MI-CADMI-CAD in relatives; age- and sex-adjusted; MI-CAD in 12.2% of relatives; mean follow-up 8.5 ± 4.8 years
1.43(1.37–1.49)
Observational data: associations, not effects.
Original publication
Familial risk of myocardial infarction with non-obstructive and obstructive coronary arteries: a nation-wide cohort study. Eur J Prev Cardiol. Published 7 October 2024. doi:10.1093/eurjpc/zwae313
Summarised from the published abstract; every number is checked against it