Arrhythmias & electrophysiologyCohort study
Familial risk of sinus node dysfunction indicating pacemaker implantation: a nationwide cohort study
- Nationwide register-based cohort study
Authors' conclusion
First-degree relatives to SND patients are at increased risk of SND with risk being inversely associated with pacemaker implantation age in the index person. Mortality in first-degree relatives was comparable with the general population, although subgroup findings suggest an increased mortality among individuals with a family history of early-onset SND.
Study context
- Population
- Danish individuals born after 1954, followed 1982–2022
- Participants
- 6,027,090 individuals · 180,775,041 person-years
- Exposure
- Relatives vs General population
- Outcome
- Pacemaker-treated sinus node dysfunction (SND)
Main finding
Pacemaker-treated SND
Adjusted relative risk
2.9
CI 2.4–3.6
By group
Relatives
0.79
cumulative incidence at age 68 years · %
General population
0.27%
cumulative incidence at age 68 years
Relatives vs General population
adjusted RR 2.9 (CI 2.4–3.6)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | RR (CI) | |
|---|---|---|
| Pacemaker-treated SND, index implantation age ≤60 years (subgroup) | 5.5 (3.4–9.0) | |
| Mortality, index onset ≤60 years (subgroup) | 1.22 (1.05–1.41) | |
| 0.10.31310Relative risk (log scale) |
- Pacemaker-treated sinus node dysfunction (SND), index implantation age ≤60 years (subgroup): risk inversely proportional to implantation age in index person
Mortality
- Overall mortality similar between relatives and general population
Original publication
Familial risk of sinus node dysfunction indicating pacemaker implantation: a nationwide cohort study. Europace. Published 13 November 2024. doi:10.1093/europace/euae287
Summarised from the published abstract; every number is checked against it