Aortic & peripheral vascular disease
Feasibility and Restenosis Predictors of Optical Frequency Domain Imaging-Guided Drug-Coated Balloon Treatment for Femoropopliteal Lesions
Authors' conclusion
OFDI-guided DCB treatment is feasible in selected femoropopliteal lesions. An OFDI-detected calcified nodule is associated with an increased risk of restenosis after DCB treatment for femoropopliteal lesions.
Study context
- Population
- Patients with symptomatic, nonseverely calcified femoropopliteal lesions who underwent drug-coated balloon (DCB) treatment under optical frequency domain imaging (OFDI) guidanceanalyzable lesions, 202 lesions initially enrolled, of which 35 (17.3%) were excluded primarily because of severe calcification or inadequate OFDI data
- Participants
- 167 patients
- Exposure
- OFDI findings during OFDI-guided DCB treatment associated with restenosis
- Outcome
- Restenosis of the target lesion (peak systolic velocity ratio of ≥2.5 by duplex ultrasound at rest or target lesion revascularization)
- Follow-up
- 1 year
Main finding
As reported in the abstract
1-year freedom from restenosis
85.5%
Observational data: associations, not effects.
Further findings
Restenosis by procedural OFDI finding: calcified nodule in the target lesion
| Comparison | Subdistribution hazard ratio for restenosis (95% CI) | P value | |
|---|---|---|---|
| Calcified nodule in the target lesionComparator not stated | 3.25 (1.01–10.42) | P = 0.048 | |
| 0.050.21520Subdistribution hazard ratio for restenosis (log scale) |
Procedural success (residual stenosis of less than 30% without flow compromise and without any procedural complications)
- Procedural success rate
- 91.6%
Original publication
Feasibility and Restenosis Predictors of Optical Frequency Domain Imaging-Guided Drug-Coated Balloon Treatment for Femoropopliteal Lesions. JACC Cardiovasc Interv. Published 9 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it