Arrhythmias & electrophysiologyCohort study
Feasibility, procedural efficiency, and early imaging outcomes of concomitant pulsed field ablation and left atrial appendage closure: a prospective single-centre study
- Prospective cohort study
- single-centre
Authors' conclusion
Combined PFA and LAAC is feasible and safe with favourable early outcomes.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing combined pulsed field ablation (PFA) and left atrial appendage closure (LAAC) in routine practice
- Participants
- 209 patients
- Exposure
- Concomitant PFA and LAAC
- Outcome
- Workflow, safety and feasibility of combined PFA and LAAC
Main finding
As reported in the abstract
Procedural efficiency
Mean procedure time
57.3 ± 17 min
Mean left atrial dwell time
45.1 ± 13.6 min
Mean fluoroscopy time for LAAC
3.4 ± 0.8 min
Observational data: associations, not effects.
Further findings
LAAC device use and seal
- Single LAAC device used
- 94%
- Adequate seal achieved in all
Follow-up imaging (CT 80% or TEE 20%) · 111.6 ± 16.5 days
- Small-leak rate
- 4.7%
- Device-related thrombi, without stroke, managed with extended anticoagulation
- two
- No leaks >2 mm
Safety
Procedural complications
- Minor groin bleeding
- two patients
- No pericardial effusion, phrenic nerve injury, kidney or oesophageal injury
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Feasibility, procedural efficiency, and early imaging outcomes of concomitant pulsed field ablation and left atrial appendage closure: a prospective single-centre study. Europace. Published 6 February 2026. doi:10.1093/europace/euag017
Summarised from the published abstract; every number is checked against it