Arrhythmias & electrophysiologyCohort study
Fibrosis-4 Index Reflects the Severity of Tricuspid Regurgitation and Patient Prognosis in Atrial Fibrillation
- Retrospective cohort study
- single-centre
Authors' conclusion
In patients with atrial fibrillation, FIB-4 was positively associated with TR severity and an increased risk of all-cause mortality.
Study context
- Population
- AF patients with complete biochemical and echocardiographic data
- Participants
- 4,919 patients
- Exposure
- High FIB-4 vs low FIB-4
- Outcome
- All-cause death
- Follow-up
- Median 3.9 years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.357
95% CI 1.183–1.555
P < 0.001
High FIB-4 vs Low FIB-4
aHR 1.357 (95% CI 1.183–1.555); P < 0.001
- Overall mortality
- 2694 (54.8%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause mortality, isolated TR (subgroup) | 1.930 (1.330–2.801) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Significant tricuspid regurgitation (TR)
- Positive correlation between significant TR and FIB-4 (multivariable regression)
Original publication
Fibrosis-4 Index Reflects the Severity of Tricuspid Regurgitation and Patient Prognosis in Atrial Fibrillation. Eur J Heart Fail. Published 14 July 2025. doi:10.1002/ejhf.3761
Summarised from the published abstract; every number is checked against it