Heart failure & cardiomyopathiesSecondary analysis
Finerenone, Glycaemic Status, and Heart Failure with Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial
- Secondary analysis of the FINEARTS-HF randomised trial
- prespecified analysis
Authors' conclusion
In patients with HF with mildly reduced/preserved ejection fraction, the beneficial effects of finerenone, compared with placebo, on clinical events and symptoms, were consistent, irrespective of glycaemic status at baseline.
Study context
- Population
- Heart failure (HF) with NYHA II–IV, LVEF ≥40%, structural heart disease and elevated NT-proBNP; subgroups by glycaemic status (normoglycaemia, pre-diabetes, diabetes)
- Participants
- 6,001 participants
- Comparison
- Finerenone vs placebo, by glycaemic status
- Primary endpoint
- CV death and total worsening HF events
Primary result
As reported in the abstract
CV death and total worsening HF events, finerenone vs placebo by glycaemic status
Finerenone vs PlaceboRelative risk (95% CI)
normoglycaemia
0.85(0.63–1.14)
pre-diabetes
0.85(0.66–1.08)
diabetes
0.82(0.69–0.98)
Further findings
| Outcome | Values | adjusted RR (95% CI) | |
|---|---|---|---|
| Primary endpoint rate by glycaemic status (vs normoglycaemia) — Pre-diabetes vs Normoglycaemia | 1.02 (0.84–1.23) | ||
| Primary endpoint rate by glycaemic status (vs normoglycaemia) — Diabetes vs Normoglycaemia | 1.32 (1.11–1.58) | ||
| 0.512Adjusted relative risk (log scale) |
| Outcome | Values | Estimate |
|---|---|---|
| Glycaemic status at baseline | Normoglycaemia 20.8% · Pre-diabetes 33.1% · Diabetes 46.2% |
Components of primary outcome, all-cause death, composite kidney endpoints, KCCQ total symptom score improvement
- Effects of finerenone not modified by glycaemic status
Original publication
Finerenone, Glycaemic Status, and Heart Failure with Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial. Eur J Heart Fail. Published 10 April 2025. doi:10.1002/ejhf.3649
Summarised from the published abstract; every number is checked against it