Prevention & lipidsCohort study
Fitness does not retire: cardiorespiratory fitness and risk of major adverse cardiovascular events in older adults
- Prospective cohort study
Authors' conclusion
In older Norwegian adults, higher CRF was inversely associated with long-term risk of MACE.
Study context
- Population
- Older Norwegian adults aged 70–77 years, Generation 100 Study, examined 2012–2013784 women
- Participants
- 1,547 adults
- Exposure
- Fit vs unfit
- Outcome
- MACE:
- First acute MI
- Stroke
- HF
- CV death
- Follow-up
- Median 10.0 years (IQR 9.2-10.0)
Main finding
As reported in the abstract
MACE by baseline VO2peak
Fit vs UnfitSubdistribution hazard ratio (95% CI)
men (VO2peak ≥26.0 mL/kg/min)
0.76(0.54–0.99)
women (VO2peak ≥22.2 mL/kg/min)
0.59(0.39–0.90)
- Total major adverse cardiovascular events (MACE) events
- 294 (185 men, 109 women)
Observational data: associations, not effects.
Further findings
| Outcome | sHR (95% CI) | |
|---|---|---|
| MACE by one-year fitness trajectory (remained fit vs remained unfit) — Remained fit vs Remained unfit · men; 36% lower risk | 0.64 (0.42–0.99) | |
| MACE by one-year fitness trajectory (remained fit vs remained unfit) — Remained fit vs Remained unfit · women; 42% lower risk | 0.58 (0.33–0.99) | |
| 0.20.5125Subdistribution hazard ratio (log scale) |
Original publication
Fitness does not retire: cardiorespiratory fitness and risk of major adverse cardiovascular events in older adults. Eur J Prev Cardiol. Published 30 August 2026. doi:10.1093/eurjpc/zwag450
Summarised from the published abstract; every number is checked against it