Arrhythmias & electrophysiologyCohort study
Five-year changes in weight and risk of atrial fibrillation in the Danish Diet, Cancer, and Health Cohort
- Prospective cohort study
Authors' conclusion
Five-year weight gain was associated with greater risk of AF compared with stable weight in the Danish Diet, Cancer, and Health Cohort. There was no statistically significant association between weight loss and risk of AF.
Study context
- Population
- Participants without prior atrial fibrillation (AF), Danish Diet, Cancer, and Health Cohort; Body mass index (BMI) at baseline and 5 years later
- Participants
- 43,758 participants
- Exposure
- 5-year weight change vs stable weight
- Outcome
- Incident AF
- Follow-up
- Median 15.7 years
Main finding
As reported in the abstract
Each group vs stable weightHazard ratio (95% CI)
Weight gain 2.5–5 BMI units
1.24(1.09–1.41)
Weight gain ≥5 BMI units
1.95(1.48–2.56)
Observational data: associations, not effects.
Further findings
Incident AF, whole cohort · median follow-up 15.7 years
- Individuals with incident AF
- 5312
- Incidence rate
- 8.6/1000 person-years
Original publication
Five-year changes in weight and risk of atrial fibrillation in the Danish Diet, Cancer, and Health Cohort. Eur J Prev Cardiol. Published 14 September 2023. doi:10.1093/eurjpc/zwad300
Summarised from the published abstract; every number is checked against it