Arrhythmias & electrophysiology
Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion
Authors' conclusion
Flow dynamic parameters may be able to predict the risk of DRT after LAAO.
Study context
- Population
- Patients who underwent left atrial appendage occlusion (LAAO) with pre- and post-CT imaging
- Participants
- 38 patients
- Comparison
- Device-related thrombosis (DRT) vs no DRT after LAAO
- DRTn = 19
- Without DRTn = 19reference
- Outcome
- Flow dynamic factors (time averaged wall shear stress, oscillatory shear index, endothelial cell activation potential) correlating to DRT
Methodological detailsmulticentre registry, computational fluid dynamic simulations
- Multicentre registry
- Computational fluid dynamic simulations
Main finding
As reported in the abstract
Flow dynamic parameters
| Group | Time averaged wall shear stress | Oscillatory shear index | Endothelial cell activation potential |
|---|---|---|---|
| DRT | 1.76 ± 1.24 Pa | 0.19 ± 0.11 | 0.23 ± 0.58 Pa-1 |
| Without DRT | 2.90 ± 2.70 Pa | 0.17 ± 0.11 | 0.17 ± 0.30 Pa-1 |
Time averaged wall shear stress
DRT1.76 ± 1.24 Pa
Without DRT2.90 ± 2.70 Pa
Oscillatory shear index
DRT0.19 ± 0.11
Without DRT0.17 ± 0.11
Endothelial cell activation potential
DRT0.23 ± 0.58 Pa-1
Without DRT0.17 ± 0.30 Pa-1
- DRT: significantly lower time averaged wall shear stress, higher oscillatory shear index and higher endothelial cell activation potential than controls
- P < 0.001 for all
Observational data: associations, not effects.
Further findings
Left atrium volume and mitral valve area
- Larger in DRT than controls
Original publication
Flow Dynamic Factors Correlated With Device-Related Thrombosis After Left Atrial Appendage Occlusion. JACC Adv. Published 15 October 2024. doi:10.
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