Prevention & lipids

Flow-Mediated Dilation in Competitive Athletes: Non-linear Associations and Haemodynamic Characteristics

Eur J Prev CardiolPublished Systematic review and meta-analysis

Pooled resultResult — go to the resultSMD 0.33 95% CI −0.01 to 0.66

Authors' conclusion

No clear overall difference in FMD was observed between athletes and controls.

Study context

Population
Controlled studies reporting resting ultrasound-assessed conduit-artery flow-mediated dilation (FMD) in competitive athletes and non-athletic controls
Comparison
Competitive athletes vs non-athletic controls
Outcome
Resting FMD
Methodological detailsthree-level random-effects model, GRADE
  • Three-level random-effects model
  • GRADE

Pooled result

As reported in the abstract

SMD

0.33

95% CI −0.01 to 0.66

P = 0.06

Athletesvs Controls
SMD 0.33 (95% CI −0.01 to 0.66); P = 0.06

Further pooled results

FMD by sport modality (subgroup)

Sport modality associated with variation in effect estimates; endurance athletes showed higher FMD than controls; evidence for strength and mixed-modality sports less conclusive

FMD vs age and VO2max (exploratory quadratic meta-regression)

Possible curved associations with age and VO2max; fitted turning points not validated physiological thresholds
  • Exploratory

Original publication

Flow-Mediated Dilation in Competitive Athletes: Non-linear Associations and Haemodynamic Characteristics. Eur J Prev Cardiol. Published 16 September 2026. doi:10.1093/eurjpc/zwag493

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