Arrhythmias & electrophysiologyResearch article
Focal pulsed field ablation of ventricular tachycardia in patients with structural heart disease: Procedural characteristics, acute endpoints, and early-to-midterm outcomes
- single-center study
- consecutive patients
Authors' conclusion
Focal PFA for VT in SHD was feasible and was associated with high acute noninducibility and encouraging early freedom from VT recurrence, including in predominantly septal substrates. Larger studies are needed to define durability and optimal dosing strategies.
Study context
- Population
- Patients with structural heart disease (SHD) undergoing ventricular tachycardia (VT) ablation using focal pulsed field ablation (PFA)
- Participants
- 16 consecutive patients
Main finding
As reported in the abstract
Acute procedural success (noninducibility of any sustained or nonsustained VT at the end of the procedure) · end of the procedure
Focal PFA
88%
14 of 16 of 16
Further findings
| Outcome | Values |
|---|---|
| VT recurrence · median follow-up of 130 days | Focal PFA 3 events |
- VT recurrence — Freedom from VT recurrence
- 81%
Baseline and procedural characteristics
- Mean age
- 66 ± 11 years
- Nonischemic cardiomyopathy
- 9 patients (64%)
- Mean left ventricular ejection fraction
- 43% ± 11%
- Septal substrate targeted
- 11 patients (69%)
- Mean procedure time
- 138 ± 34 minutes
- PFA applications per case
- 58 ± 26
Safety
| Outcome | Values |
|---|---|
| Major complications | Focal PFA 6% |
- Major complications — Pericardial tamponade
- 1 patient
Major complications
- No deaths, strokes, or myocardial infarctions
Original publication
Focal pulsed field ablation of ventricular tachycardia in patients with structural heart disease: Procedural characteristics, acute endpoints, and early-to-midterm outcomes. Heart Rhythm. Published 25 June 2026. doi:10.1016/j.hrthm.2026.06.021
Summarised from the published abstract; every number is checked against it