HypertensionRandomised controlled trial
Fractional Flow Reserve–Guided Renal Artery Stenting in Renovascular Hypertension
- Randomised controlled trial
- investigator-initiated
- multicentre
- open-label
- blinded endpoint adjudication
- 1:1
Authors' conclusion
At the 1-year follow-up, FFR-guided renal artery stenting reduced stent use without loss of blood pressure control or renal safety compared with angiography guidance.
Study context
- Population
- Adults with atherosclerotic renal artery stenosis (ARAS)1-year follow-up: 50 fractional flow reserve (FFR)-guided, 51 angiography-guided
- Participants
- 107 adults
- Comparison
- FFR-guided vs angiography-guided renal artery stenting
- Primary endpoint
- % change in ambulatory daytime mean SBP (DMSBP), composite index of antihypertensive medicines (CIAHM) and renal outcomes
- Follow-up
- 1 year
Primary result
As reported in the abstract
DMSBP, CIAHM and renal outcomes
- Daytime mean systolic blood pressure (DMSBP), composite index of antihypertensive medicines (CIAHM) and renal outcomes similar between the groups
Further findings
Stenting rate · 1 year
P < 0.01
ΔDMSBP in patients with FFR <0.80 who underwent stenting (subgroup)
- 3 months, median [IQR]
- 13 [4, 21] mm Hg
- 6 months, median [IQR]
- 8 [3, 16] mm Hg
- 12 months, median [IQR]
- 7 [0, 16] mm Hg
- all paired P < 0.05
CIAHM decline in patients with FFR <0.80 who underwent stenting (subgroup) · 3, 6 and 12 months
- Median [IQR] decline
- 2 [0, 5]
- all paired P < 0.05
12-month eGFR after stenting
- Significant eGFR improvement only when FFR <0.80
- quantile regression analysis
Original publication
Fractional Flow Reserve–Guided Renal Artery Stenting in Renovascular Hypertension. JACC Cardiovasc Interv. Published 13 July 2026. doi:10.1016/j.jcin.2026.05.019
Summarised from the published abstract; every number is checked against it