Coronary disease & ACSSecondary analysis
Fractional Flow Reserve to Guide Revascularization in Patients With Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement (TAVR)
- Secondary analysis of the NOTION-3 randomised trial and registry
Authors' conclusion
Conservative management of FFR ≤0.80 lesions was linked to higher cardiovascular risk compared with either PCI of FFR ≤0.80 lesions or deferral of FFR >0.80 lesions, which had similar outcomes.
Study context
- Population
- Severe AS scheduled for TAVR with ≥50% coronary stenosis
- Participants
- 587 participants
- Comparison
- Fractional flow reserve (FFR) ≤0.80 conservative vs FFR ≤0.80 percutaneous coronary intervention (PCI) vs FFR >0.80 defer
- FFR ≤0.80 conservativen = 232
- FFR ≤0.80 PCIn = 220
- FFR >0.80 defern = 135
- Primary endpoint
- CV death, MI and/or urgent revascularization
- Follow-up
- 36 months
Primary result
As reported in the abstract
CV death, MI or urgent revascularization (cumulative incidence)
- Difference across the three groups
- P = 0.003
Further findings
Revascularization, coronary lesion level
- Revascularization, coronary lesion level — Difference across segments
- P < 0.0001
Original publication
Fractional Flow Reserve to Guide Revascularization in Patients With Coronary Artery Disease Undergoing TAVR. JACC Cardiovasc Interv. Published 8 December 2025. doi:10.1016/j.jcin.2025.10.015
Summarised from the published abstract; every number is checked against it