Frailty and long-term outcomes in younger patients with acute myocardial infarction
Authors' conclusion
Frailty is independently associated with poor outcomes after AMI, with the strongest impact observed in younger patients
Study context
- Population
- Patients with acute MI in England and Wales, stratified by age (<55, 55–74, ≥75 years)13% severely frail
- Participants
- 931,133 patients
- Exposure
- Frailty categories by age group
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Methodological detailslinked national administrative data
- Linked national administrative data
Main finding
As reported in the abstract
All-cause mortality, severe frailty, by age group
Adjusted hazard ratio (95% CI)
Severevs Fityoung patients (<55 years)
6.69(5.76–7.76)
Severevs Fitmiddle-aged patients (55-74 years)
4.33(4.11–4.57)
Severevs Fitolder patients (≥75 years)
2.31(2.23–2.39)
- Severe, younger vs Severe, older · age × frailty interaction
- fold higher risk 3.51 (95% CI 3.11–3.96); P < 0.001
Observational data: associations, not effects.
Original publication
Frailty and long-term outcomes in younger patients with acute myocardial infarction. Eur Heart J. Published 25 November 2025. doi:10.
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