Heart failure & cardiomyopathiesCohort study
Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure
- Prospective cohort study
- nationwide
- multicentre
- registry
Authors' conclusion
The CFS is an independent predictor of 2-year mortality and a robust integrative measure of physical and cognitive vulnerability in patients with heart failure.
Study context
- Population
- Hospitalized patients with HF (JROADHF-NEXT registry)
- Participants
- 3,905 patients
- Exposure
- Clinical Frailty Scale (CFS) categories
- Outcome
- All-cause mortality after discharge
- Follow-up
- 2 years
Main finding
As reported in the abstract
2-year all-cause mortality
Deaths over 2-year follow-up (all patients)
725 (18.6%)
Observational data: associations, not effects.
Further findings
Physical function and Mini-Cog scores by CFS
- Physical function metrics and Mini-Cog scores progressively worsened with increasing CFS severity
Prognostic discrimination
- Adding CFS significantly improved discrimination vs model based on Short Physical Performance Battery (SPPB) and Mini-Cog
Original publication
Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure. J Am Coll Cardiol. Published 15 October 2025. doi:10.1016/j.jacc.2025.09.1590
Summarised from the published abstract; every number is checked against it