Frequency and Prognosis of Alternative Definitions of Occlusion Myocardial Infarction Across the Whole Spectrum of Acute Coronary Syndromes
- MATRIX trial
Authors' conclusion
OMI defined by impaired CA flow confers prognostic implications beyond the presence or absence of ST-segment elevation in a broad ACS population and identifies patients without ST-segment elevation with 1-year mortality similar to that of STEMI.
Study context
- Population
- Patients across the whole spectrum of acute coronary syndromes (ACS) from the MATRIX trialpatients with ACS
- Participants
- 6,558 patients
- Comparison
- Five alternative occlusion myocardial infarction (OMI) definitions and their association with 1-year all-cause mortality
Main finding
As reported in the abstract
OMI frequency
Further findings
1-year all-cause mortality
| Comparison | adjusted HR (95% CI) | |
|---|---|---|
| OMI definition 1 · higher mortality with OMI | 2.08 (1.56–2.78) | |
| OMI definition 2 · higher mortality with OMI | 1.97 (1.47–2.63) | |
| OMI definition 3 · higher mortality with OMI | 1.70 (1.25–2.32) | |
| OMI definition 4 · higher mortality with OMI | 1.47 (1.01–2.12) | |
| OMI definition 5 · not associated | 1.26 (0.90–1.75) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Discrimination, reclassification and model fit added to STE/NSTE-ACS classification
- OMI definitions exclusively based on impaired culprit artery (CA) flow (ie, definitions 1-3) improved discrimination, reclassification, and model fit
1-year mortality, NSTE-ACS with OMI definition 1 or 2 vs STEMI
- One-year mortality did not differ
Original publication
Frequency and Prognosis of Alternative Definitions of Occlusion Myocardial Infarction Across the Whole Spectrum of Acute Coronary Syndromes. JACC Cardiovasc Interv. Published 12 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it