Heart failure & cardiomyopathiesCohort study
Fulminant myocarditis: outcome predictors in an international cohort study
- Retrospective cohort study
- multicentre
- 26 European tertiary centres
- consecutive patients
Endomyocardial biopsy (EMB) inconclusive (n = 48) or not performed (n = 77) analysed separately
Authors' conclusion
In-hospital mortality among patients with FM remains high.
Study context
- Population
- Consecutive adults admitted for fulminant myocarditis (FM), 26 European tertiary centres, January 2012–November 2022146 with histopathologic diagnosis
- Participants
- 271 adults
- Exposure
- Histopathologic subtypes of FM
- Lymphocytic (LM)n = 99
- EMn = 18
- NEMn = 3
- Giant-cell myocarditis (GCM)n = 26
- Outcome
- In-hospital and 1-year mortality
- Follow-up
- In-hospital and 1 year
Main finding
As reported in the abstract
1-year mortality by histopathology · 1 year
- In-hospital mortality, overall population
- 31%
- 1-year mortality, overall population
- 34%
- Difference in 1-year mortality across histopathologic subgroups
- P = 0.04
Observational data: associations, not effects.
Further findings
Heart transplant during follow-up
- Heart transplant
- 17 patients (6%)
Functional outcome in survivors to discharge
- Excellent functional outcome and long-term recovery of ventricular function
Original publication
Fulminant myocarditis: outcome predictors in an international cohort study. Eur Heart J. Published 10 September 2025. doi:10.1093/eurheartj/ehaf671
Summarised from the published abstract; every number is checked against it