Heart failure & cardiomyopathies
Functional and Prognostic Implications of Different Iron Deficiency Definitions in Heart Failure: Insights From HEART-FID
Authors' conclusion
Despite ferritin <100 ng/mL being the most common ID criteria met in HEART-FID, Tsat and iron and their changes over time, more than ferritin, were related to functional capacity, hemoglobin levels, and prognosis.
Study context
- Population
- Patients with heart failure (HF), LVEF ≤40% and iron deficiency (ID) (ferritin <100 ng/mL or <300 ng/mL with transferrin saturation (Tsat) <20%) in the HEART-FID trial of ferric carboxymaltose vs placebocomplete baseline iron studies
- Participants
- 2,951 patients
- Comparison
- Different ID definitions and iron indices (ferritin, Tsat, serum iron) in relation to functional capacity, hemoglobin and outcomes
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Fulfilment of ID criteria and association with hemoglobin, functional capacity and outcomes · baseline
Ferritin <100 ng/mL
89.8%
Iron <13 μM
59.8%
Tsat <20%
40.5%
Ferritin <30 ng/mL
31.1%
Further findings
- Tsat and iron remained associated with hemoglobin and 6MWD after multivariable adjustment; changes in Tsat and iron over 6 months related to changes in hemoglobin and 6MWD
Original publication
Functional and Prognostic Implications of Different Iron Deficiency Definitions in Heart Failure: Insights From HEART-FID. JACC Heart Fail. Published 25 October 2025. doi:10.
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