Heart failure & cardiomyopathies
Functional Assessment Based on Cardiopulmonary Exercise Testing in Mild Heart Failure: A Multicentre Study
Main findingResult — go to the resultAUC 0.55 95% CI 0.51–0.59Authors' conclusion
Patients with chronic HF classified as NYHA I overlapped substantially with those classified as NYHA II in objective physiological measures and prognosis.
Study context
- Population
- Consecutive heart failure (HF) patients in New York Heart Association (NYHA) class I or II undergoing cardio-pulmonary exercise test (CPET) in three Brazilian centres42% NYHA I, 58% NYHA II
- Participants
- 688 patients
- Exposure
- NYHA class I vs NYHA class II
- Outcome
- CPET parameters by NYHA class (kernel density overlap) and discrimination by % predicted peak VO2
Methodological detailsmulticentre, consecutive patients, 3 Brazilian centres
- Multicentre
- Consecutive patients
- 3 Brazilian centres
Main finding
As reported in the abstract
AUC
0.55
95% CI 0.51–0.59
P = 0.005
- Kernel density overlap NYHA I vs II, % predicted peak VO2
- 86%
- Kernel density overlap NYHA I vs II, VE/VCO2 slope
- 89%
- Kernel density overlap NYHA I vs II, oxygen uptake efficiency slope (OUES)
- 84%
- Absolute probability increment of NYHA I classification when % predicted peak VO2 increased from 50% to 100%
- 13%
Observational data: associations, not effects.
Further findings
- All-cause mortality — NYHA class III patients displayed a distinctively higher death rate · not significantly different
- P < 0.001 · P = 0.41
Global CPET parameters (all patients)
- Median % predicted peak VO2 (IQR 56-80)
- 66.8%
- Median VE/VCO2 slope (31.6-43.3)
- 36.9
- Mean OUES (±0.59)
- 1.51
Original publication
Functional Assessment Based on Cardiopulmonary Exercise Testing in Mild Heart Failure: A Multicentre Study. ESC Heart Fail. Published 21 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →