Heart failure & cardiomyopathies
Galectin-3 Levels and Long-Term All-Cause Mortality and Hospitalization in Heart Failure Patients: A Meta-Analysis
Authors' conclusion
Higher circulating galectin-3 levels after hospitalization of HF patients are linearly and positively associated with the risk of long-term ACM and ACM/HFR.
Study context
- Population
- Patients with heart failure (HF), follow-up >6 months24 cohort studies
- Comparison
- Highest vs lowest circulating galectin-3 levels
- Outcome
- All-cause mortality (ACM); ACM or HF-related rehospitalization (ACM/HFR)
- Follow-up
- >6 months
Methodological detailsrandom-effects model, dose-response analysis
- Random-effects model
- Dose-response analysis
Pooled result
As reported in the abstract
Hazard ratio (95% CI)P value
Higher galectin-3ACM; I2 = 66%
1.65(1.28–2.13)
Higher galectin-3ACM/HFR; I2 = 76%
1.52(1.15–2.00)
1 ng/mL increase in galectin-3ACM
1.04(1.02–1.06)
P = 0.0021 ng/mL increase in galectin-3ACM/HFR
1.03(1.02–1.04)
P < 0.001Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Per 1 ng/mL increase in galectin-3 (dose-response)Per 1 ng/mL increase · ACM | 1.04 (1.02–1.06) | P = 0.002 | |
| Per 1 ng/mL increase in galectin-3 (dose-response)Per 1 ng/mL increase · ACM/HFR | 1.03 (1.02–1.04) | P < 0.001 | |
| Per 1-SD increase in galectin-3Per 1-SD increase · long-term ACM; I2 = 42% | 1.29 (1.13–1.48) | ||
| Per 1-SD increase in galectin-3Per 1-SD increase · ACM/HFR; I2 = 60% | 1.22 (1.07–1.38) | ||
| Per 1-log increase in galectin-3Per 1-log increase · long-term ACM; I2 = 41% | 1.98 (1.48–2.65) | ||
| Per 1-log increase in galectin-3Per 1-log increase · ACM/HFR; I2 = 7% | 1.83 (1.02–3.28) | ||
| 0.20.5125Hazard ratio (log scale) |
Correlation of baseline galectin-3 with NT-proBNP and eGFR
- Moderate positive correlation with N terminal pro brain natriuretic peptide (P = 0.045)
- r = 0.48
- Weak negative correlation with eGFR (P = 0.077)
- r = −0.39
Original publication
Galectin-3 Levels and Long-Term All-Cause Mortality and Hospitalization in Heart Failure Patients: A Meta-Analysis. ESC Heart Fail. Published 3 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →