Heart failure & cardiomyopathiesCohort study
Gender and Race Differences in HeartMate3 Left Ventricular Assist Device as a Bridge to Transplantation
- Retrospective cohort study
- registry (OPTN database)
Authors' conclusion
Use of HM3 among patients listed for HT has increased over time and by gender and race. Black patients with HM3 were less likely to be transplanted compared with White patients, but there were no differences in post-transplant outcomes between these groups or between men and women.
Study context
- Population
- Patients listed for heart transplantation (HT) who received left ventricular assist device (LVADs) as bridge to transplantation (BTT), OPTN database, January 2018–June 2020955 (8.3%) with HM3 as BTT
- Participants
- 11,524 patients
- Exposure
- Outcomes with HM3 LVAD as BTT by gender and race
- Outcome
- Use of HM3, waitlist outcomes (transplantation; death/delisting) and post-transplant outcomes by gender and race
Main finding
As reported in the abstract
Waitlist outcomes (competing risk)
Adjusted hazard ratio (95% CI)
Men vs WomenHT
0.92(0.70–1.21)
Men vs Womendeath/delisting
0.91(0.59–1.42)
Black vs WhiteHT
0.72(0.57–0.91)
Black vs Whitedeath/delisting
1.36(0.98–1.89)
- Use of HM3 increased for all patients; no difference in use by gender
- P = 0.4
- No difference in HM3 use by race
- P = 0.2
Observational data: associations, not effects.
Further findings
1-year post-transplant survival
- Comparable by gender
- 0.52 [95% CI: 0.21-1.70] (aHR [95% CI])
- Comparable by race
- 0.76 [95% CI: 0.34-1.70] (aHR [95% CI])
Post-transplant stroke, acute rejection, graft failure
- No differences in rates of stroke, acute rejection or graft failure
Original publication
Gender and Race Differences in HeartMate3 Left Ventricular Assist Device as a Bridge to Transplantation. JACC Heart Fail. Published 3 January 2024. doi:10.1016/j.jchf.2023.11.008
Summarised from the published abstract; every number is checked against it