Prevention & lipidsCohort study
Gender differences in cardiovascular events among patients with sleep apnoea syndrome: a real-world data analysis of a nationwide epidemiological dataset
- Retrospective cohort study
- nationwide claims database
- Cox regression, multivariable-adjusted
Authors' conclusion
Despite the lower prevalence of SAS among women, there was a gender disparity in the cardiovascular impact of SAS, with women demonstrating a significantly higher risk compared with men.
Study context
- Population
- Adults in the JMDC Claims Database, Japan, without central sleep apnoea syndrome (SAS) or cardiovascular disease (CVD)2,406,930 men · 1,766,772 women
- Participants
- 4,173,702 adults
- Exposure
- SAS vs no SAS, by sex
- Outcome
- Composite CV events
- Follow-up
- Mean 1290 ± 1000 days
Main finding
As reported in the abstract
Composite CV events, by sex (subgroup analysis)
SAS vs No SASHazard ratio (95% CI)
men
1.27(1.23–1.31)
women
1.72(1.54–1.92)
- Association significantly stronger in women than men; validated by sensitivity analyses
- P for interaction < 0.001
Observational data: associations, not effects.
Further findings
SAS prevalence by sex
Original publication
Gender differences in cardiovascular events among patients with sleep apnoea syndrome: a real-world data analysis of a nationwide epidemiological dataset. Eur J Prev Cardiol. Published 28 January 2025. doi:10.1093/eurjpc/zwaf029
Summarised from the published abstract; every number is checked against it