Coronary disease & ACSCohort study
Gender-related risk of myocardial infarction and subclinical coronary atherosclerosis: a Danish population cohort study
- Prospective population cohort study
Authors' conclusion
For the same degree of subclinical coronary atherosclerosis, women may have a lower risk of myocardial infarction than men.
Study context
- Population
- Asymptomatic women and men >40 years in a Danish general population cohort, undergoing coronary CT angiography
- Participants
- 5,710 vs 4,293
- Exposure
- Women vs Men
- Womenn = 5,710
- Menn = 4,293
- Outcome
- Myocardial infarction
Main finding
As reported in the abstract
MI, obstructive vs no obstructive subclinical coronary atherosclerosis · median follow-up 6.0 years (IQR 3.9-9.5)
Adjusted hazard ratio (95% CI)
Women
4.1(1.5–11)
Men
12(4.6–34)
Observational data: associations, not effects.
Secondary outcomes
Prevalence of subclinical coronary atherosclerosis, women vs men · From 40 through to >80 years of age
- Women had less subclinical coronary atherosclerosis than men, with and without CV risk factors
- P for gender interaction <.0001
Death or MI combined, obstructive vs no obstructive subclinical coronary atherosclerosis · Median follow-up 6.0 years (IQR 3.9-9.5)
- Women: HR
- 1.9 (1.3-2.9) (95% CI)
- Men: HR
- 2.7 (1.9-3.9) (95% CI)
- P for gender interaction = .30
Clinically driven coronary revascularization, obstructive vs no obstructive subclinical coronary atherosclerosis · Median follow-up 6.0 years (IQR 3.9-9.5)
- Women: HR
- 23 (5.2-106) (95% CI)
- Men: HR
- 34 (11-106) (95% CI)
- P for gender interaction = .35
Original publication
Gender-related risk of myocardial infarction and subclinical coronary atherosclerosis: a Danish population cohort study. Eur Heart J. Published 12 August 2026. doi:10.1093/eurheartj/ehag612
Summarised from the published abstract; every number is checked against it