Arrhythmias & electrophysiologyCohort study
General anaesthesia and deep sedation for monopolar pulsed field ablation using a lattice-tip catheter combined with a novel three-dimensional mapping system
- Observational cohort study
Authors' conclusion
The use of a novel ablation platform in conjunction with a lattice-tip catheter in deep sedation is feasible, effective, and associated with significantly shorter lab occupancy time when compared with GA.
Study context
- Population
- Patients with symptomatic paroxysmal or persistent atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI) and additional linear lesion sets35% female, 75% persistent AF
- Participants
- 63 patients
- Exposure
- General anaesthesia (GA) vs Deep sedation
- GAn = 23reference
- Deep sedationn = 40
Main finding
As reported in the abstract
Acute efficacy (PVI rate) and procedural times, GA vs deep sedation
PVI rate
| Outcome | GA | Deep sedation | P value |
|---|---|---|---|
| Procedure time (mean ± SD) | 96 ± 24 min | 100 ± 23 min | P = 0.52 |
| Lab occupancy time (mean ± SD) | 165 ± 40 min | 131 ± 35 min | P = 0.0008 |
| Dose area product | 489 (216;1093) cGycm2 | 452 (272;882) cGycm2 | P = 0.82 |
Observational data: associations, not effects.
Further findings
Procedure time
P = 0.52
Lab occupancy time
P = 0.0008
Dose area product · spread as printed in parentheses; kind not named
P = 0.82
Safety
| Outcome | GA | Deep sedation |
|---|---|---|
| Pericardial tamponade | Not reported in the abstract | 1 events |
Original publication
General anaesthesia and deep sedation for monopolar pulsed field ablation using a lattice-tip catheter combined with a novel three-dimensional mapping system. Europace. Published 22 November 2024. doi:10.1093/europace/euae270
Summarised from the published abstract; every number is checked against it