Valvular & structural heart disease
Generalisable artificial intelligence ECG trained on public data for outcome prediction after transcatheter aortic valve replacement
Authors' conclusion
An AI-ECG model trained solely on publicly available data provides accurate and generalisable prediction of outcomes after TAVR using a single ECG. This approach demonstrates the feasibility of transparent, shareable AI models for cardiovascular risk stratification and supports a general-to-specific paradigm for clinical deployment.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR)prospective TAVR validation cohort, model trained on 341,151 publicly available ECGs with mortality labels
- Participants
- 439 patients
- Predictors
- Transformer-based AI-ECG model applied to a single pre-procedural ECG
- Predicted outcome
- 30-day and 1-year mortality
Methodological detailstrained exclusively on publicly available data, prospective external validation cohort, additionally tested in a surgical aortic valve replacement cohort
- Trained exclusively on publicly available data
- Prospective external validation cohort
- Additionally tested in a surgical aortic valve replacement cohort
Model performance
As reported in the abstract
AUC
30-day mortality
0.85(95% CI 0.78 to 0.92)
1-year mortality
0.74(95% CI 0.67 to 0.80)
- TAVR cohort, single pre-procedural ECG
Further findings
Predictive performance in independent surgical cohort
- Predictive performance was consistent in an independent surgical cohort
1-year mortality, major adverse cardiac events and major renal events (AI-ECG risk score association)
- AI-ECG risk score, adjusted OR for 1-year mortality
- 1.70
- Independently associated with major adverse cardiac events and major renal events
- Multivariable regression
High-risk ECG features
- Atrial fibrillation, prolonged QT interval, ST-T abnormalities and low voltage
Original publication
Generalisable artificial intelligence ECG trained on public data for outcome prediction after transcatheter aortic valve replacement. Heart. Published 28 May 2026. doi:10.
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