Prevention & lipidsCross-sectional study
Genetic and clinical factors underlying a self-reported family history of heart disease
- Cross-sectional study
Authors' conclusion
A combined model of clinical and genetic risk factors explains only 36% of the likelihood of FHHD, implying additional value in the family history.
Study context
- Population
- UK Biobank participants without pre-existing CAD
- Participants
- 166,714 participants
- Outcome
- Self-reported family history of heart disease (FHHD), associations with clinical and genetic risk factors and population attributable risks (PAR)
Main finding
As reported in the abstract
Association of risk factors with FHHD (multivariable model) and PAR
OR
PRSCADpolygenic risk score for CAD
1.30(CI 1.27–1.33)
HeFHheterozygous familial hypercholesterolemia
1.31(CI 1.11–1.54)
Hypertension
1.18(CI 1.15–1.21)
Lipoprotein(a)
1.17(CI 1.14–1.20)
Apolipoprotein B-to-apolipoprotein AI ratio
1.13(95% CI 1.10–1.16)
Triglycerides
1.07(CI 1.04–1.10)
Population attributable risks (PAR)
- Clinical factors
- 21.9% (CI 18.19–25.63)
- Genetic factors
- 22.2% (CI 20.44–23.88)
- Genetic and clinical factors combined
- 36.0% (CI 33.31–38.68)
- Participants reporting an family history of heart disease (FHHD)
- 72 052 (43.2%)
Observational data: associations, not effects.
Original publication
Genetic and clinical factors underlying a self-reported family history of heart disease. Eur J Prev Cardiol. Published 3 April 2023. doi:10.1093/eurjpc/zwad096
Summarised from the published abstract; every number is checked against it