HypertensionMeta-analysis
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure
- Genome-wide association study meta-analysis
- polygenic risk score analyses
- phenome-wide association study
Authors' conclusion
These findings advance the understanding of the genetic architecture of childhood BP and HR and provide compelling genetic evidence linking childhood BP to a broad spectrum of adult health outcomes-particularly cardiometabolic conditions
Study context
- Population
- Children of European ancestry aged 4–17 years; follow-up in independent cohorts of diverse ancestries and the UK BiobankHR n = 22,565
- Participants
- 28,425 children
- Outcome
- Genetic loci for childhood SBP, DBP, pulse pressure, mean arterial pressure and HR
Pooled result
As reported in the abstract
Genome-wide significant loci for childhood blood pressure (BP) (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2)
8
Loci for childhood HR (CCDC141, ACHE, MYH6); all novel in children, previously reported in adults
3
Further pooled results
Variance explained by childhood polygenic risk score (PRSs) (European ancestry)
- BP variance, up to
- 1.6%
- HR variance, up to
- 5.2%
Genetic correlation, childhood vs adult BP traits
- Moderate (rg), suggesting age-specific genetic effects
- 0.4-0.7
Childhood BP PRS and adult outcomes (UK Biobank)
- Higher PRS significantly associated with broad range of adult outcomes, particularly hypertension, angina, MI and CVD-related mortality
Original publication
Summarised from the published abstract; every number is checked against it