Heart failure & cardiomyopathiesCohort study
Genetic determinants of severity and recurrence in arrhythmia-induced cardiomyopathy
- Retrospective cohort study
- multicentre
Authors' conclusion
Arrhythmia-induced cardiomyopathy patients exhibit a substantial prevalence of deleterious variants in cardiomyopathy-associated genes, particularly TTN truncating variants. Genotype-positive individuals represent a high-risk subgroup with greater familial burden, more severe clinical presentation and increased recurrence risk.
Study context
- Population
- Patients with arrhythmia-induced cardiomyopathy (AF) undergoing genetic testing of cardiomyopathy-associated genes
- Participants
- 100 patients
- Exposure
- Genotype-positive vs genotype-negative
- Genotype-positiven = 16
- Outcome
- Prevalence and clinical impact of deleterious variants in cardiomyopathy-associated genes
Main finding
As reported in the abstract
Prevalence of genotype-positive status
Genotype-positive
16%
16 of 16
- TTN truncating variants share of variants
- 75%
Observational data: associations, not effects.
Further findings
Family history of cardiomyopathy
P = 0.005
Family history of sudden death
P = 0.034
EF
P = 0.034
Cardiogenic shock
P = 0.012
Recurrence
P = 0.028
Original publication
Genetic determinants of severity and recurrence in arrhythmia-induced cardiomyopathy. Eur J Heart Fail. Published 25 May 2026. doi:10.1093/ejhf/xuag181
Summarised from the published abstract; every number is checked against it