HypertensionCohort study
Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women
- Prospective cohort study
- multicentre
Authors' conclusion
Lower genetic risk and higher first-trimester CVH were independently and additively associated with lower risk of developing HDPs in nulliparous individuals.
Study context
- Population
- Genotyped nulliparous individuals with singleton pregnancies, nuMoM2b cohort, 8 US sites, 2010–2013mean age 27.0 years
- Participants
- 7,499 individuals
- Exposure
- High vs low genetic risk and low vs high first-trimester cardiovascular health (CVH)
- Outcome
- Development of HDP (preeclampsia/eclampsia or gestational hypertension)
Main finding
As reported in the abstract
HDP
Adjusted odds ratio (95% CI)P value
High genetic risk vs Low genetic risk
2.21(1.78–2.77)
P < 0.001Low CVH vs High CVH
2.92(2.28–3.74)
P < 0.001- Participants developing HDP overall
- 1,032 (13.8%)
- HDP incidence, low genetic risk + high CVH
- 4.5%
- HDP incidence, high genetic risk + low CVH
- 25.7%
- High vs low CVH: lower HDP risk across genetic risk strata
- 53%-74%
- No significant interaction between genetic risk and CVH
- P for interaction > 0.05
Observational data: associations, not effects.
Further findings
HDP subtypes
- Preeclampsia
- 487 [6.5%]
- Gestational hypertension
- 545 [7.3%]
- Findings consistent for preeclampsia/eclampsia and gestational hypertension separately
First-trimester CVH score
- Median CVH score
- 77.1 (Q1-Q3: 67.1-85.7)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women. J Am Coll Cardiol. Published 15 April 2025. doi:10.1016/j.jacc.2025.02.015
Summarised from the published abstract; every number is checked against it