Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease
Authors' conclusion
Genetic variants in CYP7A1 which are associated with increased levels of LDL cholesterol, are associated with an increased risk of both MI and GSD.
Study context
- Population
- Individuals from the general populationMyocardial infarction (MI) in 2326, gallstone disease (GSD) in 2007
- Participants
- 100,149 individuals
- Exposure
- CYP7A1 weighted allele score >0.04 vs ≤0
- Outcome
- MI and symptomatic GSD
- Follow-up
- Mean 7 years (0-23 years)
Methodological detailsgeneral population cohort, weighted allele scores
- General population cohort
- Weighted allele scores
Main finding
As reported in the abstract
Score >0.04 vs Score ≤0Hazard ratio (95% CI)P value
MI; multifactorially adjusted
1.25(1.10–1.41)
P = 5 × 10-4for trendGSD; multifactorially adjusted
1.39(1.22–1.59)
P = 2 × 10-7for trendObservational data: associations, not effects.
Further findings
LDL-C, rare mutations (highest vs lowest allele count)
- Increase in LDL-C
- 12% (0.4 mmol/L)
- P for trend = 3 × 10-4
LDL-C, common variants (score >0.04 vs ≤0)
- Stepwise increase in LDL-C of up to
- 2.4% (0.08 mmol/L)
Meta-analyses including large consortia data
- Results were similar
Original publication
Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease. Eur Heart J. Published 23 February 2018. doi:10.
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