Heart failure & cardiomyopathies
Genotype is Associated with Left Ventricular Reverse Remodelling and Early Events in Recent-Onset Dilated Cardiomyopathy
Authors' conclusion
RODCM patients harbouring class 4-5 non-TTN VOIs are at higher risk of progressive heart failure and life-threatening ventricular arrhythmias.
Study context
- Population
- Czech patients with recent-onset dilated cardiomyopathy (symptom duration ≤6 months) undergoing genetic counselling and whole-exome sequencing (WES) (72 cardiomyopathy-related genes)
- Participants
- 386 patients
- Exposure
- Class 4-5 variants of interest (VOIs) vs negative genetic testing
- TTNtvn = 69
- non-TTN VOIsn = 56
- Outcome
- All-cause death, heart transplantation or ventricular assist device implantation
- Follow-up
- Median 41 months
Main finding
As reported in the abstract
- Class 4-5 non-TTN VOIs, but not TTNtv, an independent baseline predictor of the primary outcome
- Class 4-5 VOIs in nuclear envelope genes an independent baseline predictor of the primary outcome
Observational data: associations, not effects.
Secondary outcomes
Ventricular arrhythmia event (secondary outcome)
- Class 4-5 non-TTN VOIs an independent baseline predictor
- Negative genetic testing strongly protective against life-threatening ventricular arrhythmias
- Nuclear envelope gene VOIs an independent predictor at baseline and after 12 months
- Cytoskeleton gene VOIs associated with increased risk after baseline assessment
Left ventricular reverse remodelling (LVRR) · 12 months
- Class 4-5 non-TTN VOIs, but not TTNtv, heralded lower probability of 12-month LVRR
- Positive family history of DCM alone related only to lower probability of LVRR at 12 months and final follow-up
Original publication
Genotype is Associated with Left Ventricular Reverse Remodelling and Early Events in Recent-Onset Dilated Cardiomyopathy. ESC Heart Fail. Published 11 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →