Coronary disease & ACSCohort study
Geographic variation in long-term health outcomes following myocardial infarction in England
- cohort study
Authors' conclusion
This research provides region-specific data for the incidence of 10 major health outcomes following MI in England. The findings can support commissioners to target resources to those areas with populations at greatest risk of major health outcomes following MI.
Study context
- Population
- All adults ≥18 years of age with index myocardial infarction (MI) admitted to hospital within all 106 integrated care board (ICB) subpopulations in England (2008–2017)individuals with MI (n=2,807,195 hospital admissions)
- Participants
- 381,518 adults
- Exposure
- Variation in incidence of health outcomes following MI between ICB subpopulations within England
Main finding
As reported in the abstract
Crude incidence of post-MI health outcomes, range between areas · within 9 years of follow-up
heart failure
20.2%-47.9%
severe bleeding
14.3%-34.6%
renal failure
23.7%-38.0%
all-cause mortality
34.3%-47.7%
Observational data: associations, not effects.
Further findings
Adjusted incidence of each major health outcome by ICB subpopulation
- Fell within expected range (between 95% control limits) after adjusting for patient demographics, except two sub-ICBs in Lancashire and South Cumbria, where rates were higher than expected
Variation explained at ICB subpopulation level (intraclass correlation coefficient (ICC))
- ICC for all outcomes
- <5%
- variation predominantly explained by region-specific patient demographic profiles
Original publication
Geographic variation in long-term health outcomes following myocardial infarction in England. Heart. Published 31 August 2026. doi:10.1136/heartjnl-2025-327671
Summarised from the published abstract; every number is checked against it